Mer receptor tyrosine kinase is a promising novel cancer therapeutic target in many human Golf Simulator Screen cancers, because abnormal activation of Mer has been implicated in survival signaling and chemoresistance.3D-QSAR analyses based on alignment independent descriptors were performed on a series of 81 Mer specific tyrosine kinase inhibitors
Non-muscle myosin II (NMII) form bipolar filaments, which bind F-actin to exert cellular contractility during physiological processes (Vicente-Manzanares et al., 2009).Using a combinatorial approach to fluorescently label both N- and C-termini of the NMII heavy chain, recent works have demonstrated the ability to visualize NMII bipolar filaments at
Dynamical phase transitions extend the notion of criticality to nonstationary settings and are characterized by sudden changes in the macroscopic properties of time-evolving quantum systems.Investigations of dynamical phase transitions combine aspects of symmetry, topology, and nonequilibrium physics; however, progress has been hindered by the noto
Responding to the call for reform in science education, changes were made in an introductory meteorology and climate course offered at a large public university.These changes were a part of a larger project aimed at deepening and extending a program of science content courses that model effective teaching strategies for prospective middle school sc